Campylobacter vaccine

Application Number: 00104982
Application Date: 2000.04.07
Publication Number: 1270061
Publication Date: 2000.10.18
Priority Information: 1999/4/9 EP 99201086.8
International: A61K39/106;A61K39/395;A61P31/04
Applicant(s) Name: Akzo Nobel N. V.
Inventor(s) Name: A. A. C. Zakobuhs;J. F. V. D. Bosch;P. J. M. Nuetann
Patent Agency Code: 11038
Patent Agent: huang gesheng
Abstract The present invention relates to vaccines comprising antiserum raised against a flagellaless Campylobacter strain for the prevention of Campylobacter colonisation in animals. The invention also relates to antigenic Campylobacter proteins visible in a Western blot of Campylobacter jejuni protein after incubation of said Western blot with antibodies against a flagellaless mutant of Campylobacter jejuni and not visible after incubation of said blot with antibodies against wild type Campylobacter jejuni, and to their use in vaccines and the manufacturing thereof. The invention further relates to vaccines comprising such proteins and antibodies against such proteins. The invention further relates to the use of such Campylobacter proteins and to antiserum and antibodies raised against Campylobacter antigens for the preparation of vaccines. Finally, the invention relates to methods for the preparation of such vaccines.