Dual-plasmid gene vaccine resisting against hepatitis B virus, and its preparing process and application

Application Number: 00107853
Application Date: 2000.06.19
Publication Number: 1316518
Publication Date: 2001.10.10
Priority Information: 1999/6/18 CN 99109076.4
International: C12N15/79;A61K39/29;A61P1/16
Applicant(s) Name: Hospital No.458, PLA
Inventor(s) Name: Chen Guangming;Xie Zongfa;Yang Fuqiang
Patent Agency Code: 11223
Patent Agent: wang mengxia
Abstract A dual-plasmid gene vaccine resisting hepatitis B virus and its preparing process and application are disclosed. Said gene vaccine is composed of the molecular protein gene eukaryon expression plasmid HBV p S2.S containing colony stimulating factor GM-CSF signal sequence of granulocyte or macrophage and the human IL-2 and IFN-r fusion protein gene eukaryon expression carrier adjuvant pFP containing irrelevant intermediate sequence. The application of the DNA vaccine in treating hepatitis B virus infection is also investigated.