Growth chalone as one genetic engineering matter and its live carrier vaccine

Application Number: 00107295
Application Date: 2000.05.09
Publication Number: 1267724
Publication Date: 2000.09.27
Priority Information:
International: A61K39/42;C12N15/09;C12N15/12;C12N15/62;C12N15/863
Applicant(s) Name: Nanjing Agricultural Univ.
Address:
Inventor(s) Name: Du Nianxing;Yang Hong;Ji Chuanyi
Patent Agency Code: 11002
Patent Agent: qian baoyang
Abstract The present invention relates to hi-tech research in biological technology. Synthesized SS gene is connected to hepatitis B surface antigen (HBsAg) gene to constitute HBs/as fusion gene, which is then cloned to the vaccine virus expressing carrier (pGJP-5) to screen out the recombined vaccine virus (vv-HBs/ss) expressing HBsAg/ss fusion protein through syngeneic recombination with vaccine virus. The gene engineering body is proliferated on chick embryo chorio allantoic membrane to produce growth chalone gene engineering live carrier vaccine. Test shows that the vaccine is easy to produce, has no environmental pollution and can immunize pig, ox, sheep and other livestock effectively and safely.