Improved method for sgnthesizing 6,9-bis[(2-aminoethyl) amino] benz[g] isoquinoline-5, 10-diketone and its dimaleate

Application Number: 00104930
Application Date: 2000.03.29
Publication Number: 1282738
Publication Date: 2001.02.07
Priority Information: 1994/3/28 US 220007
International: C07D221/08
Applicant(s) Name: Novas Pharmaceutical S.P.A.
Inventor(s) Name: S. Schpinaili;R. Didomanikow
Patent Agency Code: 72001
Patent Agent: wen hongyan
Abstract In the search for novel heteroanalogs of anthracendiones, 6,9-bis[(2-aminoethyl)amino]benzo[g]isoquinoline-5,10-dione dimaleate salt (BBR 2778), was selected as the most promising compound. New methods of synthesis produce the compound in purity greater than 99%.