Nucleoside 5'-thiophosphoryl amino-acid ester compound


Application Number  00129555 Application Date  2000.10.09
Publication Number  1290707 Publication Date  2001.04.11
Priority Information    
International
Classification
 C07H19/20  
Applicant(s) Name  Qinghua Univ.  
Address    
Inventor(s) Name  Zhao Yufen;Miao Zhiwei;Han Bo  
Patent Agency Code  11201 Patent Agent  luo wenqun
AbstractNucleoside 5'-thiiophosphoryl amino acid ester compound is prepared through the processes of dissolving thiophosphoryl trichloride in dried tetrahydrofuran, addition of carbamate hydrochloride through stirring, dripping acid binding agent to react, filtering, rotating distillation to eliminate solvent and other low boiling point matters, hydrolysis in ammonia water and final silica gel chromatography. The compound of the present invention may be used in developing medicine with antiviral, antitumor and HIV resisting activity.