Phosphodiesterase inhibitor and its use

Application Number: 00106987
Application Date: 2000.04.26
Publication Number: 1292264
Publication Date: 2001.04.25
Priority Information: 1999/4/30 US 60/132036
International: A61J1/00;A61J3/00;A61K9/00;A61K31/4985;A61P3/10;A61P9/10;A61P15/08;A61P27/02
Applicant(s) Name: Lillyeckes Co., Ltd.
Inventor(s) Name: J.T. Emik;K.M. Fierguson;W.E. Pullyman
Patent Agency Code: 72001
Patent Agent: zhang anyu
Abstract The present invention relates to highly selective phosphodiesterase(PDE)enzyme inhibitors and to their use in pharmaceutical articles of manufacture. In particular, the present invention relates to potent inhibitors of cyclic guanosine 3',5'-monophosphate specific phosphodiesterase type 5(PDE5)that when incorporated into a pharmaceutical product at about 1 to about 20 mg unit dosage are useful for the treatment of sexual dysfunction. The articles of manufacture described herein are characterized by PDE5 inhibition, and accordingly, provide a benefit in therapeutic areas where inhibition of PDE5 is desired, with minimization or elimination of adverse side effects resulting from inhibition of other phosphodiesterase enzymes and with an improvement of vascular conditioning.