Process for synthesizing nucleotide and the like

Application Number: 00107145
Application Date: 2000.05.10
Publication Number: 1275575
Publication Date: 2000.12.06
Priority Information: 1999/5/11 US 60/133651
International: C07H19/02
Applicant(s) Name: Pfizer Inc.
Address:
Inventor(s) Name: R. W. Scott
Patent Agency Code: 72001
Patent Agent: wang jingchao
Abstract The present invention relates to an improved method for synthesizing nucleosides with a low alpha : beta anomeric ratio. The method comprises coupling a protected furanosyl halide and an appropriately protected heterocycle in the presence of a nucleophilic polar solvent and a strong base.