Synthesis of mannitose-glucose tetrasaccharide repeated unit with anti-tumor activity


Application Number: 00107722
Application Date: 2000.05.24
Publication Number: 1324798
Publication Date: 2001.12.05
Priority Information:
International: A61P35/00;C07H3/06;C08B37/02
Applicant(s) Name: Ecological Environment Research Center, Chinese Academy of Sciences
Address:
Inventor(s) Name: Ning Jun;Zhu Yuliang;Kong Fanzuo
Patent Agency Code: 00000
Patent Agent:
Abstract The synthesis of tetrasaccharide repeating unit of manno-glucosan which possesses biological activity and can be used as anti-cancer medicine includes the following steps: firstly, coupling the benzoylated mannose trichloroacetyliminoester with glucose whose 3-position is free hydroxyl group to obtain disaccharide, then making acid hydrolysis and selectively removing 4,6-benzal group or 5,6 isopropylidene group, and selectively coupling with another benzoylated mannose trichloroacetyliminoester at 6-position to obtain trisaccharide, making acid hydrolysis and removing 1,2-position ethylidene group or isopropylidene group; after activation, coupling with monosaccharide receptor whose 4-position is free hydroxyl group, and making deprotection so as to obtain the tetrasaccharide repeating unit.