Treating synergist composite and its usage


Application Number: 00108186
Application Date: 2000.04.29
Publication Number: 1307901
Publication Date: 2001.08.15
Priority Information: 1990/5/11 US 522,360
International: A61K31/401;A61K38/55
Applicant(s) Name: Pfizer Inc.
Address:
Inventor(s) Name: Anthony A Fosa
Patent Agency Code: 72001
Patent Agent: tan mengsheng
Abstract This invention relates to compositions and methods for achieving a therapeutic effect such as lowering blood pressure and treating congestive heart failure in a mammal. More specifically, this invention relates to synergistic compositions comprising amounts of at least two therapeutic agents selected from the group consisting of a renin inhibitor, an angiotensin I converting enzyme inhibitor and an angiotensin II antagonist. Further, this invention relates to methods for achieving synergistic therapeutic effects which methods comprise administering to said mammal, either sequentially in any order or simultaneously, amounts of at least two therapeutic agents selected from the group consisting of a renin inhibitor, an angiotensin I converting enzyme inhibitor and an agiotensin II antagonist, in amounts sufficient to achieve a synergistic therapeutic effect.