Erythrocyte-stimulating factor coupling

Application Number: 00107889
Application Date: 2000.06.29
Publication Number: 1280137
Publication Date: 2001.01.17
Priority Information: 1999/7/2 US 60/142254; 1999/8/23 US 60/150225; 1999/8/31 US 60/151548; 1999/11/17 US 60/166151
International: A61K38/17;A61P13/12;C07K14/505
Applicant(s) Name: Hoffmann-La Roche & Co. AG
Inventor(s) Name: Pascar sabastian Bairon
Patent Agency Code: 11021
Patent Agent: hu jiaoyu
Abstract The present invention refers to conjugates of erythropoietin with poly(ethylene glycol) comprising an erythropoietin glycoprotein having at least one free amino group and having the in vivo biological activity of causing bone marrow cells to increase production of reticulocytes and red blood cells and selected from the group consisting of human erythropoietin and analogs thereof which have sequence of human erythropoietin modified by the addition of from 1 to 6 glycosylation sites or a rearrangement of at least one glycosylation site; said glycoprotein being covalently linked to 'n' poly(ethylene glycol) groups of the formula -CO-(CH2)x-(OCH2CH2)m-OR.