Application Number: 00103440
Application Date: 2000.03.14
Publication Number: 1267664
Publication Date: 2000.09.27
Priority Information:
International: C07C221/00;C07C225/16
Applicant(s) Name: Li Jianfu
Address:
Inventor(s) Name: Li Jianfu;Yang Rongjie;Yu Qisheng
Patent Agency Code: 00000
Patent Agent:
Abstract In the present invention, various levorotary comphorsulfonic acid and its bromide is used to separate racemic metamfepyramone in water as solvent to obtain levorotary metamfepyramone salt, which is dissolved in water and mixed with isoequivalent ammonia water or barium hydrochloride and organic solvent to obtain levorotary metamfepyramone from organic solvent with the mother liquor being mixed with sulfuric acid to eliminate inorganic salt. The mother liquor after separation is mixed with isoequivalent ammonia water or barium hydrochloride, heated to racemize, mixed with iso-equivalent sulfuric acid and filtered to eliminate inorganic salt, cooled to crystallize and separate levorotary metamfepyramone; or the mother liquor is heated directly to racemize in the protection of acid and cooled to crystallize and separate levorotary metamfepyramone salt.