Separation of Amlodipine antimer

Application Number: 00102701
Application Date: 2000.02.21
Publication Number: 1267669
Publication Date: 2000.09.27
Priority Information:
International: C07D211/90
Applicant(s) Name: Zhang Xitian
Inventor(s) Name: Zhang Xitian
Patent Agency Code: 00000
Patent Agent:
Abstract The present invention provides the practical method of separating the two antimers of racemic Amlodipine, (R)-(+)- Amlodipine and (S)-(-)-Amlodipine by using tartaric acid as chiral reagent and hexadeuterio dimethyl sulfoxide (MDSO-d6) as chiral assistant.